diff --git a/src/core/streaming.ts b/src/core/streaming.ts
index 3ea5f21524..d05f8faac9 100644
--- a/src/core/streaming.ts
+++ b/src/core/streaming.ts
@@ -114,16 +114,44 @@ export class Stream<Item> implements AsyncIterable<Item> {
 
     async function* iterLines(): AsyncGenerator<string, void, unknown> {
       const lineDecoder = new LineDecoder();
+      const reader = readableStream.getReader();
+      let closed = false;
+      let cancelPromise: Promise<void> | undefined;
+      const cancel = () => {
+        cancelPromise ??= reader.cancel();
+        cancelPromise.catch(() => {});
+      };
 
-      const iter = ReadableStreamToAsyncIterable<Bytes>(readableStream);
-      for await (const chunk of iter) {
-        for (const line of lineDecoder.decode(chunk)) {
-          yield line;
+      controller.signal.addEventListener('abort', cancel, { once: true });
+      try {
+        if (controller.signal.aborted) {
+          cancel();
+          return;
         }
-      }
 
-      for (const line of lineDecoder.flush()) {
-        yield line;
+        while (true) {
+          const { value: chunk, done } = await reader.read();
+          if (done) {
+            closed = true;
+            break;
+          }
+          if (controller.signal.aborted) return;
+
+          for (const line of lineDecoder.decode(chunk)) {
+            if (controller.signal.aborted) return;
+            yield line;
+          }
+        }
+
+        if (controller.signal.aborted) return;
+        for (const line of lineDecoder.flush()) {
+          if (controller.signal.aborted) return;
+          yield line;
+        }
+      } finally {
+        controller.signal.removeEventListener('abort', cancel);
+        if (!closed) cancel();
+        reader.releaseLock();
       }
     }
 
@@ -141,7 +169,7 @@ export class Stream<Item> implements AsyncIterable<Item> {
         done = true;
       } catch (e) {
         // If the user calls `stream.controller.abort()`, we should exit without throwing.
-        if (isAbortError(e)) return;
+        if (controller.signal.aborted || isAbortError(e)) return;
         throw e;
       } finally {
         // If the user `break`s, abort the ongoing request.
diff --git a/src/lib/responses/ResponseStream.ts b/src/lib/responses/ResponseStream.ts
index 1761f4bbfb..f7246076ac 100644
--- a/src/lib/responses/ResponseStream.ts
+++ b/src/lib/responses/ResponseStream.ts
@@ -7,6 +7,7 @@ import {
   type ResponseStreamEvent,
 } from '../../resources/responses/responses';
 import { RequestOptions } from '../../internal/request-options';
+import { type ReadableStream } from '../../internal/shim-types';
 import { APIUserAbortError, OpenAIError } from '../../error';
 import OpenAI from '../../index';
 import { type BaseEvents, EventStream } from '../EventStream';
@@ -90,6 +91,12 @@ export class ResponseStream<ParsedT = null>
     return runner;
   }
 
+  static fromReadableStream(stream: ReadableStream): ResponseStream<null> {
+    const runner = new ResponseStream(null);
+    runner._run(() => runner._fromReadableStream(stream));
+    return runner;
+  }
+
   #beginRequest() {
     if (this.ended) return;
     this.#currentResponseSnapshot = undefined;
@@ -198,6 +205,23 @@ export class ResponseStream<ParsedT = null>
     return this.#endRequest();
   }
 
+  protected async _fromReadableStream(
+    readableStream: ReadableStream,
+    options?: RequestOptions,
+  ): Promise<ParsedResponse<ParsedT>> {
+    this._listenForAbort(options?.signal);
+    this.#beginRequest();
+    this._connected();
+    const stream = Stream.fromReadableStream<ResponseStreamEvent>(readableStream, this.controller);
+    for await (const event of stream) {
+      this.#addEvent(event, null);
+    }
+    if (stream.controller.signal?.aborted) {
+      throw new APIUserAbortError();
+    }
+    return this.#endRequest();
+  }
+
   [Symbol.asyncIterator](this: ResponseStream<ParsedT>): AsyncIterator<ResponseStreamEvent> {
     const pushQueue: ResponseStreamEvent[] = [];
     const readQueue: {
diff --git a/tests/lib/ResponseStream.test.ts b/tests/lib/ResponseStream.test.ts
index d23449b34c..b54b162d18 100644
--- a/tests/lib/ResponseStream.test.ts
+++ b/tests/lib/ResponseStream.test.ts
@@ -1,8 +1,136 @@
+import { APIUserAbortError } from 'openai';
+import { ReadableStreamFrom } from 'openai/internal/shims';
+import { ResponseStream } from 'openai/lib/responses/ResponseStream';
+import type { Response, ResponseStreamEvent } from 'openai/resources/responses/responses';
 import { makeStreamSnapshotRequest } from '../utils/mock-snapshots';
 
 jest.setTimeout(1000 * 30);
 
 describe('.stream()', () => {
+  it('creates a response stream from a readable stream', async () => {
+    const events: ResponseStreamEvent[] = [
+      {
+        type: 'response.created',
+        sequence_number: 0,
+        response: makeResponse(),
+      },
+      {
+        type: 'response.output_item.added',
+        sequence_number: 1,
+        output_index: 0,
+        item: {
+          id: 'msg_123',
+          type: 'message',
+          role: 'assistant',
+          status: 'in_progress',
+          content: [],
+        },
+      },
+      {
+        type: 'response.content_part.added',
+        sequence_number: 2,
+        item_id: 'msg_123',
+        output_index: 0,
+        content_index: 0,
+        part: {
+          type: 'output_text',
+          annotations: [],
+          text: '',
+        },
+      },
+      {
+        type: 'response.output_text.delta',
+        sequence_number: 3,
+        item_id: 'msg_123',
+        output_index: 0,
+        content_index: 0,
+        delta: 'Hello world',
+        logprobs: [],
+      },
+      {
+        type: 'response.completed',
+        sequence_number: 4,
+        response: makeResponse({
+          status: 'completed',
+          output_text: 'Hello world',
+          output: [
+            {
+              id: 'msg_123',
+              type: 'message',
+              role: 'assistant',
+              status: 'completed',
+              content: [{ type: 'output_text', annotations: [], text: 'Hello world' }],
+            },
+          ],
+        }),
+      },
+    ];
+    const snapshots: string[] = [];
+    const stream = ResponseStream.fromReadableStream(readableStreamFromEvents(events)).on(
+      'response.output_text.delta',
+      (event) => snapshots.push(event.snapshot),
+    );
+    const emittedEvents: ResponseStreamEvent[] = [];
+
+    for await (const event of stream) {
+      emittedEvents.push(event);
+    }
+
+    const final = await stream.finalResponse();
+
+    expect(emittedEvents).toEqual(events);
+    expect(snapshots).toEqual(['Hello world']);
+    expect(final.output_text).toBe('Hello world');
+    expect(final.output[0]).toMatchObject({
+      type: 'message',
+      content: [{ type: 'output_text', text: 'Hello world' }],
+    });
+  });
+
+  it('cancels a stalled readable stream when aborted', async () => {
+    const encoder = new TextEncoder();
+    const created = {
+      type: 'response.created',
+      sequence_number: 0,
+      response: makeResponse(),
+    } satisfies ResponseStreamEvent;
+
+    let resolvePullStarted!: () => void;
+    const pullStarted = new Promise<void>((resolve) => {
+      resolvePullStarted = resolve;
+    });
+    let resolveCancelled!: () => void;
+    const cancelled = new Promise<void>((resolve) => {
+      resolveCancelled = resolve;
+    });
+    const cancel = jest.fn(() => resolveCancelled());
+    let pulls = 0;
+    const readable = new ReadableStream({
+      pull(controller) {
+        if (pulls++ === 0) {
+          controller.enqueue(encoder.encode(`${JSON.stringify(created)}\n`));
+          return;
+        }
+
+        resolvePullStarted();
+        return new Promise<void>(() => {});
+      },
+      cancel,
+    });
+    const stream = ResponseStream.fromReadableStream(readable);
+
+    await stream.emitted('response.created');
+    await pullStarted;
+
+    const done = expect(stream.done()).rejects.toThrowError(APIUserAbortError);
+    stream.abort();
+
+    await cancelled;
+    await done;
+    expect(cancel).toHaveBeenCalledTimes(1);
+    expect(stream.aborted).toBe(true);
+  }, 5000);
+
   it('standard text works', async () => {
     const deltas: string[] = [];
 
@@ -59,3 +187,39 @@ describe('.stream()', () => {
     expect(final.output_text).toBe('The answer is 42');
   });
 });
+
+function readableStreamFromEvents(events: ResponseStreamEvent[]) {
+  const encoder = new TextEncoder();
+  return ReadableStreamFrom(events.map((event) => encoder.encode(JSON.stringify(event) + '\n')));
+}
+
+function makeResponse(overrides: Partial<Response> = {}): Response {
+  return {
+    id: 'resp_123',
+    object: 'response',
+    created_at: 1,
+    error: null,
+    incomplete_details: null,
+    instructions: null,
+    metadata: null,
+    model: 'gpt-5',
+    output: [],
+    output_text: '',
+    parallel_tool_calls: false,
+    status: 'in_progress',
+    temperature: null,
+    tool_choice: 'auto',
+    tools: [],
+    top_p: null,
+    max_output_tokens: null,
+    previous_response_id: null,
+    reasoning: { effort: null, summary: null },
+    service_tier: null,
+    store: true,
+    text: { format: { type: 'text' }, verbosity: null },
+    truncation: 'disabled',
+    usage: null,
+    user: null,
+    ...overrides,
+  } as Response;
+}