Issues

• Assay type from where an alignment's reads land: WGS vs WES by breadth of coverage (feasibility and validation)

  DataBiosphere/meta-disco#627 · Filter by author NoopDog opened on Oct 5, 2026

• README: document producing a run the meta-disco browser can load

  documentation
  DataBiosphere/meta-disco#625 · Filter by author NoopDog opened on Oct 5, 2026

• ANVIL_T2T_CHRY: ask for the GATK sample maps its 93,180 GenomicsDB tars were built from

  enhancement
  DataBiosphere/meta-disco#624 · Filter by author NoopDog opened on Oct 5, 2026

• Define comparability: when files from different studies can share one analysis

  enhancement
  DataBiosphere/meta-disco#619 · Filter by author NoopDog opened on Oct 4, 2026
  2

• Check the lineage graph against a workflow template written from the T2T methods

  DataBiosphere/meta-disco#618 · Filter by author NoopDog opened on Oct 4, 2026
  1

• Umbrella: experiments the T2T lineage now makes possible

  DataBiosphere/meta-disco#617 · Filter by author NoopDog opened on Oct 4, 2026
  1

• Retire the ENA validator: reconcile now compares inference with ENA

  DataBiosphere/meta-disco#613 · Filter by author NoopDog opened on Oct 3, 2026

• Move the lineage rules from CLAUDE.md into the claims contract

  DataBiosphere/meta-disco#612 · Filter by author NoopDog opened on Oct 3, 2026

• Epic: T2T datasets — trace and fill the 1000G → ENA → T2T chain

  DataBiosphere/meta-disco#608 · Filter by author NoopDog opened on Oct 3, 2026

• Tell gVCFs from VCFs by content: 165K HaplotypeCaller gVCFs are typed variants.germline

  DataBiosphere/meta-disco#607 · Filter by author NoopDog opened on Oct 3, 2026
  2

• Read fast5 HDF5 attributes: verify each NIA_CARD fast5's sample and chemistry from its own content

  DataBiosphere/meta-disco#605 · Filter by author NoopDog opened on Oct 3, 2026

• NIA_CARD fast5: join the 12,394 raw-signal files to their sequencing rows by storage folder

  DataBiosphere/meta-disco#604 · Filter by author NoopDog opened on Oct 3, 2026
  1

• Read the IDAT header: the 160 HPRC .idat files are genotyping arrays, not methylation

  DataBiosphere/meta-disco#603 · Filter by author NoopDog opened on Oct 3, 2026

• Reconciliation report: how complete the metadata is, where it came from, and totals under the headline table

  DataBiosphere/meta-disco#600 · Filter by author NoopDog opened on Oct 2, 2026

• Inherit across IGVF expression lineage: author the file.derived_from quantification rows

  DataBiosphere/meta-disco#599 · Filter by author NoopDog opened on Oct 2, 2026

• Run the consistency linter over the reconciled run, not only inference output

  DataBiosphere/meta-disco#597 · Filter by author NoopDog opened on Oct 2, 2026

• Assay and instrument for ANVIL_T2T_CHRY's 1KGP CRAMs: link each to its ENA run's reads in ANVIL_T2T, matched by read and base counts

  DataBiosphere/meta-disco#594 · Filter by author NoopDog opened on Oct 2, 2026
  2

• Show reconciled coverage beside inference coverage in the coverage report

  DataBiosphere/meta-disco#592 · Filter by author NoopDog opened on Oct 1, 2026

• Audit AnVIL workspace buckets: storage class and TDR table coverage

  DataBiosphere/meta-disco#589 · Filter by author NoopDog opened on Oct 1, 2026
  

• Archive an obsolete catalog's evidence once a newer catalog is imported

  DataBiosphere/meta-disco#588 · Filter by author NoopDog opened on Oct 1, 2026

• Let an activity-map row name its dataset, the narrowest row winning

  DataBiosphere/meta-disco#587 · Filter by author NoopDog opened on Sep 30, 2026

• Record sample and donor lineage, SampleCollectionActivity and isBiologicalChildOf, in a run's edges.jsonl

  DataBiosphere/meta-disco#582 · Filter by author NoopDog opened on Sep 30, 2026

• List gnomAD's public files in search, linked where gnomAD keeps them, starting with a v4.1 sites-VCF pilot

  DataBiosphere/meta-disco#579 · Filter by author NoopDog opened on Sep 29, 2026

• Show how each file's parent is found, in the rules report, from one declaration per kind of parent

  DataBiosphere/meta-disco#575 · Filter by author NoopDog opened on Sep 28, 2026

• Make the six dimension slot descriptions plain, fuller definitions

  DataBiosphere/meta-disco#569 · Filter by author NoopDog opened on Sep 28, 2026